Unoprostone Ophthalmic Solution
You should talk with your healthcare provider prior to using unoprostone ophthalmic solution if you have:
- An eye infection or eye swelling
- An inflammatory eye condition, such as iritis or uveitis
- Had eye surgery
- Any condition that increases your risk for macular edema (swelling of the macula, an area of the retina), such as diabetes
- Any allergies, including to medications, foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
- Wear contact lenses
- Are pregnant or thinking of becoming pregnant (see Rescula and Pregnancy)
- Are breastfeeding (see Rescula and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Unoprostone Ophthalmic Solution to learn more, including information on who should not use the drug.)
Eye pressure is measured in millimeters of mercury (mmHg). In clinical studies, unoprostone ophthalmic solution was shown to reduce eye pressure by 3 to 4 mmHg in people with an average eye pressure of 23 mmHg. An eye pressure over 22 mmHg is considered higher than normal.
Medications used to lower eye pressure usually work by either decreasing the amount of fluid produced in the eye (known as the aqueous humor) or by increasing drainage of the aqueous humor from the eye. Unoprostone ophthalmic solution is thought to work by increasing fluid drainage from the eye.
More specifically, the drug may open certain channels in the trabecular network, a sponge-like tissue in the eye that is responsible for draining aqueous humor from the eye. However, the exact way in which unoprostone ophthalmic solution works to reduce intraocular pressure is unknown.