Moxeza and Pregnancy
Because Moxeza is an eye drop, very little of the medication is expected to reach the bloodstream after normal use. Therefore, it is not expected to cause serious problems during pregnancy. However, the full risks are still unknown, so a healthcare provider will prescribe Moxeza during pregnancy only if the benefits to the mother outweigh any risks to the fetus.
Can Pregnant Women Use Moxeza?Moxeza™ (moxifloxacin eye drops) is a prescription antibiotic eye drop approved to treat bacterial conjunctivitis, an eye infection commonly called "pink eye."
Although animal studies have shown that extremely high doses of the active ingredient in Moxeza might increase the risk of certain problems during pregnancy, the very low Moxeza dosage used in humans is probably unlikely to cause such problems. However, all the possible risks to humans are not known at this time.
What Is Pregnancy Category C?The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category C is given to medicines that have not been studied in pregnant humans but do appear to cause harm to the fetus in animal studies.
In addition, medicines that have not been studied in any pregnant women or animals are automatically given a pregnancy Category C rating.
When large doses of moxifloxacin (the active ingredient in Moxeza) were given to pregnant rats, the medication did not cause birth defects. However, when extremely large doses were given to pregnant rats, it increased the risk of fetal death, low fetal weight, and slightly delayed bone development. In rabbits, the drug increased the risk of rib and vertebral defects. In monkeys, moxifloxacin increased the risk of smaller fetuses.
It is important to understand that the animal studies used exceptionally large doses of moxifloxacin -- up to 25,000 times the equivalent human dosage with the eye drops. When used in the form of an eye drop, very little moxifloxacin actually reaches the bloodstream. Therefore, it is unlikely that the problems seen in animal studies would occur with normal use of this medication.
A pregnancy Category C medicine may be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh any possible risks to the unborn child.