Precautions and Warnings With Mitomycin Ophthalmic

Before receiving mitomycin ophthalmic, there are many precautions to be aware of, including warnings on who should not use the drug and side effects that may occur. For example, this prescription medicine could cause several adverse reactions, such as cornea damage and low eye pressure, and may not be safe for use in women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving mitomycin ophthalmic (Mitosol®) if you have:
 
  • Had eye surgery in the past
  • Any allergies, including to medications, foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
 
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Mitomycin Ophthalmic Precautions and Warnings

Some warnings and precautions to be aware of prior to receiving this medication include the following:
 
  • Mitomycin ophthalmic can cause cell death. If used in high doses or left on the eye too long, it may damage the cornea (the clear outermost layer of the eye) or sclera (the white outer wall of the eye). This medication should only be applied topically at the recommended dose and left on the eye for no longer than two minutes. It should not be injected into the eye.
 
  • People treated with this medicine may be more likely to develop low eye pressure (intraocular pressure) after surgery. Low intraocular pressure, known medically as hypotony, can decrease vision.
 
  • Mitomycin ophthalmic may increase the risk for changes in the lens of the eye and cataracts (clouding of the lens), especially in people who have never had cataract surgery or other surgery to remove their natural lens. 
   
  • Mitomycin ophthalmic is a pregnancy Category X medication, which means that it may be harmful if used during pregnancy (see Mitosol and Pregnancy for more information).
 
  • It is unknown if mitomycin ophthalmic passes through breast milk. Therefore, if you are breastfeeding or plan to start, check with your healthcare provider before receiving this drug (see Mitosol and Breastfeeding).
 

Mitomycin Ophthalmic Information

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