Eyes Home > Prolensa Warnings and Precautions

If you are about to start Prolensa, it's important to know that this medication can cause problems, such as bleeding in the eye and a delay in wound healing. Other safety precautions with Prolensa involve warnings about using this drug while pregnant or breastfeeding. Also, you may not be able to use this eye medication if you have diabetes, rheumatoid arthritis, or certain allergies.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using Prolensa™ (bromfenac ophthalmic solution) if you have:
  • Rheumatoid arthritis
  • A condition that causes you to bleed easily
  • Diabetes
  • Dry eyes
  • Any other eye condition
  • Had multiple eye surgeries in a short period of time
  • Any allergies, including to medications, foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Prolensa

Some warnings and precautions to be aware of with this drug include:
  • Prolensa contains the inactive ingredient sodium sulfite. This could cause an allergic reaction in people with a sulfite sensitivity. People who are sensitive to sulfites can have reactions that range from mild symptoms to serious breathing problems and a life-threatening allergic response known as anaphylaxis. Sulfite sensitivities are more common in people with asthma, and may worsen asthma symptoms in such people. Seek immediate medication attention if you have signs of an allergic reaction, such as:
    • Hives
    • An unexplained rash
    • Difficulty breathing or swallowing
    • Swelling of the face and throat.
  • Like other nonsteroidal anti-inflammatory drug (NSAIDs) eye drops, Prolensa may slow down or delay healing. The risk of healing problems is even higher when Prolensa is used in combination with corticosteroid eye drops, which can also delay healing (see Prolensa Drug Interactions).
  • People who are allergic to aspirin (acetylsalicylic acid) or other NSAIDs could also be allergic to Prolensa. Let your healthcare provider know about all your drug allergies, including any allergies you have to nonprescription medications.
  • Prolensa can cause inflammation of the cornea (the clear tissue that covers the front part of the eye), which could lead to serious problems, including loss of vision. Let your healthcare provider know right away if you develop signs of problems with your cornea, such as:
    • Severe eye pain or redness
    • Sensitivity to the light
    • Swollen eyelids
    • Watery eyes
    • Blurred vision.
  • Although you will have some eye symptoms as a result of your surgery, side effects from your surgery are not likely to be severe and should improve relatively quickly. Do not hesitate to contact your healthcare provider if you are unsure whether any problems you are experiencing are due to the surgery or something else.
  • Certain people may have a higher risk for developing cornea problems from Prolensa use. This includes people with diabetes, rheumatoid arthritis, conditions that affect the surface of the eyes (such as dry eye syndrome), and people who had complicated eye surgeries or had multiple eye surgeries in a short period of time. Prolensa should be used with caution in such people.
  • Using this medicine for more than one day before cataract surgery or for longer than 14 days after your surgery may increase your risk for developing cornea problems. Do not use this medicine for longer than your healthcare provider recommends.
  • This medication contains benzalkonium chloride, a preservative that can be absorbed by soft contact lenses. If you wear contacts, remove them before using Prolensa, and wait at least 10 minutes after your dose to reinsert them.
  • There have been reports of increased bleeding in the eye in people who used NSAID eye drops, such as Prolensa, after eye surgery. This medication should be used cautiously in people with conditions that cause them to bleed easily, or people who are taking medicines that may increase the risk for bleeding (see Prolensa Drug Interactions).
  • Prolensa is a pregnancy Category C medication, which means it may not be safe for use during pregnancy, although the full risks are currently unknown (see Prolensa and Pregnancy).
  • It is unknown if Prolensa passes through breast milk. Therefore, if you are breastfeeding or plan to start, check with your healthcare provider before using this medication (see Prolensa and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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