Eyes Home > Precautions and Warnings With Levobunolol

There are many precautions and warnings with levobunolol to be aware of before using this medication. Because the full risks of using the eye drop during pregnancy or while breastfeeding are currently unknown, you should consult your healthcare provider before using levobunolol if you are pregnant or nursing. Also, you may not be able to use these eye drops if you have certain medical conditions, such as heart block, asthma, or a slow heart rate.

What Should I Tell My Healthcare Provider Before Taking Levobunolol?

You should talk with your healthcare provider prior to taking levobunolol hydrochloride (Betagan®) if you have:
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Levobunolol Precautions and Warnings

Some warnings and precautions to be aware of prior to taking this medication include the following:
  • Even though levobunolol is an eye drop, a significant amount of the medication may be absorbed into the bloodstream. Therefore, most of the usual warnings or precautions with other beta blockers also apply to levobunolol.
  • Like all beta blockers, levobunolol can worsen heart failure in some situations. If you have heart failure, your healthcare provider may need to monitor you very closely while you are taking levobunolol. Let your healthcare provider know immediately if your heart failure symptoms seem to worsen.
  • Beta blockers can worsen breathing problems like asthma or COPD. In many cases, levobunolol is not recommended for people with such lung problems.
  • If you have an upcoming surgery, make sure your surgeon and anesthesiologist know you are taking levobunolol, as it may affect the choice of medications used during the surgery.
  • Beta blockers can mask some of the symptoms of low blood sugar (hypoglycemia), particularly the "racing heart" feeling. This can cause serious problems for people with diabetes, who need to be able to sense that they have low blood sugar (in order to correct it before it causes life-threatening problems). Some beta blockers may also worsen low blood sugar, although it is not known if this is a problem for levobunolol.
  • Beta blockers can mask some of the symptoms of an overactive thyroid (hyperthyroidism).
  • Levobunolol can potentially interact with a number of other medications (see Drug Interactions With Levobunolol).
  • Levobunolol contains sodium metabisulfite, a sulfite substance. People with asthma are at a higher risk for allergic reactions to sulfites, compared with the general population.
  • Levobunolol is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not currently known (see Betagan and Pregnancy).
  • It is not known if levobunolol passes through breast milk in humans. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Betagan and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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