Eyes Home > Precautions and Warnings With Brinzolamide

If your healthcare provider has recommended brinzolamide, it's important to know that the eye drops contain a preservative that can bind to contact lenses. There are many other precautions to be aware of before using brinzolamide, including warnings relating to who should not take the drug and possible side effects. To help minimize risks, tell your doctor about any medical conditions you have before using this drug.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to using brinzolamide (Azopt®) if you have:
  • Liver disease, such as liver failure, cirrhosis, or hepatitis
  • Kidney disease, such as kidney failure (renal failure)
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Brinzolamide Warnings and Precautions

Some warnings and precautions to be aware of prior to using this medication include the following:
  • Brinzolamide is a sulfonamide ("sulfa" drug) and can cause serious allergic reactions in people allergic to such medications.
  • Brinzolamide has not been adequately studied in people with liver or kidney problems. As a result, this eye medication is not recommended for people with such problems.
  • Brinzolamide can potentially interact with some other medications (see Drug Interactions With Brinzolamide).
  • If you have an upcoming eye surgery or develop any other eye problems or conditions (such as an infection), check with your healthcare provider about whether you should continue to use this medication.
  • Like many eye suspensions, brinzolamide can cause temporary vision blurring. Wait until your vision clears before driving or operating heavy machinery.
  • If you wear soft contact lenses, be sure to remove them (and wait at least 15 minutes before reinserting them) before each dose of brinzolamide. This eye medicine contains a preservative (benzalkonium chloride) that can bind to soft contact lenses.
  • If you use other eye drops, make sure to separate your dose of brinzolamide and that of the other drops by at least 10 minutes.
  • Brinzolamide is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not currently known (see Azopt and Pregnancy).
  • It is unknown if brinzolamide passes through breast milk in humans. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to using the drug (see Azopt and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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