Side Effects of Levofloxacin Ophthalmic Solution

Common Side Effects

Levofloxacin ophthalmic solution has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people who received levofloxacin ophthalmic solution were carefully documented. Because very little of this medication is absorbed into the bloodstream, most of the reported side effects were localized to the eye.
For the 0.5% levofloxacin eye drop (Quixin), the most commonly reported side effects (occurring in 1 to 3 percent of people) included:
  • Temporary loss of vision
  • Fever
  • Feeling like something is stuck in the eye
  • Headaches
  • Temporary eye burning
  • Eye pain or discomfort
  • Sore throat
  • Eye sensitivity to light.
For the 1.5% eye drops (Iquix), the most commonly reported side effects (occurring in 8 to 10 percent of people) were headaches and taste changes after using the drops. Other common side effects (occurring in 1 to 2 percent of people) included:
  • Decreased vision or blurred vision
  • Diarrhea
  • Indigestion or heartburn
  • Fever
  • Infection
  • Eye irritation or discomfort
  • Eye infection
  • Throat irritation.

Uncommon Side Effects of Levofloxacin Ophthalmic Solution

Some levofloxacin ophthalmic solution side effects reported in clinical trials were very rare. Because they occurred so infrequently, it is difficult to tell if they were due to the medication or something else. Uncommon side effects that occurred in less than 1 percent of people included:
  • Allergic reactions
  • Eyelid swelling
  • Dry eyes
  • Eye itching.

Levofloxacin Eye Drop Information

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