Drug Interactions With Brimonidine/Timolol
Brimonidine/timolol may decrease the effectiveness of injectable epinephrine for treating allergic reactions. If you have a serious allergy that may require treatment with epinephrine, brimonidine/timolol might not be a good choice for you.
It is dangerous to combine methacholine with brimonidine/timolol. Doing so could cause severe, asthma-like breathing problems that are not easily corrected. These medications should never be combined.
Monoamine Oxidase Inhibitors (MAOIs)
Brimonidine/timolol should never be combined with an MAOI, due to the risk of serious interactions.
Other Beta Blockers
Brimonidine/timolol contains a beta blocker. Caution should be used if it is used with other beta blockers, especially oral beta blockers. Such combinations may increase the risk of side effects. In addition, two different beta blocker eye drops generally should not be used at the same time.
Combining reserpine with a beta blocker can increase the risk of serious side effects. You may need to be monitored very closely if you use these medications together. In some cases, brimonidine/timolol should not be combined with reserpine.
Other Eye Medications
If you use other eye medications, be sure to separate your brimonidine/timolol dosage from that of the other medications by at least 10 minutes.
Theoretically, tricyclic antidepressants may decrease the effectiveness of brimonidine/timolol, although it is unclear how significant this potential drug interaction actually is.