Drug Interactions With Brimonidine/Timolol
More Information on Drug Interactions With Brimonidine/TimololThe following sections explain in detail the potentially negative interactions that can occur when brimonidine/timolol is combined with any of the drugs listed above.
Calcium Channel Blockers
Combining brimonidine/timolol with calcium channel blockers may cause dangerously low blood pressure and, with certain calcium channel blockers, may cause a dangerously slow heart rate (bradycardia). You may need to be monitored very closely if you use these medications together. In some cases, brimonidine/timolol should not be combined with a calcium channel blocker.
Stopping clonidine without stopping brimonidine/timolol could increase the risk of dangerously high blood pressure, strokes, and other serious problems. This is more common with oral beta blockers, but could happen with brimonidine/timolol as well. If you need to stop taking clonidine but still need to take brimonidine/timolol, ask your healthcare provider for further instructions.
CYP 2D6 Inhibitors
Brimonidine/timolol is metabolized by a specific liver enzyme known as CYP 2D6. Medications known as CYP 2D6 inhibitors slow down the activity of this enzyme, causing an increase in the level of brimonidine/timolol in the blood. This could lead to serious side effects of this medication.
Different medications inhibit the enzyme to different extents; some drug interactions may be minor, while others may be quite severe. Check with your healthcare provider before combining brimonidine/timolol with a CYP 2D6 inhibitor.
Combining brimonidine/timolol with digoxin may cause a dangerously slow heart rate (bradycardia). You may need to be monitored very closely if you use these medications together. In some cases, it brimonidine/timolol should not be combined with digoxin.